The aim of this study was to investigate the effect of couple therapy according to Islamic teachings on resilience and happiness of couples. The research method was quasi-experimental with experimental and control groups and the statistical population included all couples referring to clinics in Isfahan in 2016, from which 30 couples were selected as a sample and by available sampling and replace in experimental and control groups (15 peer couples in every group). The instruments used included the Connor & Davidson Resilience Questionnaire (2010) and the Oxford Happiness Questionnaire (Argyle & Lu, 1990). After the pretest, the experimental group underwent couple therapy intervention in 10 sessions of 2 hours, but the control group did not receive any intervention. Mean, standard deviation and univariate analysis of covariance were used to analyze the data. The results of this study showed that the effect of couple therapy according to Islamic teachings on increasing resilience and happiness was significant (P <0.05)