Ebert, Martin A

Geso, Moshi

Hardcastle, Nicholas

Kelly, Jennifer

Ng, Sweet-Ping

Ryan, John

English

Monash University Research Portal

The Impact of Fluorine-18-fluoroethyltyrosine Positron Emission Tomography (F18-FET-PET) Scan Timing on Radiotherapy planning in Newly Diagnosed Patients with Glioblastoma - A Planning StudyJohn Ryana,b, Nicholas Hardcastlec, Sweet Ping Ngd, Moshi Gesoa, Jennifer Kellya and Martin A. Eberte aRMIT,  bMonash University, cPeter MacCallum Cancer Centre, dOlivia Newton-John Cancer Wellness and Research Centre, eSir Charles Gairdner HospitalType somethingESTRO-EANO recently recommended 18F-FET PET as an additional tool to assist in glioblastoma target delineation (1)Eight patients had two 18F-FET PET scans prior to starting radiation therapy (RT). These were used to created two novel target volume sets using Varian Eclipse and the Orbit - RT rapid plan model. The new volumes and plans were compared with each other and the originals using ProKnow DS and Golden Rule.   Does the 18F-FET PET scan timing change the glioblastoma clinical target volume or plan?Figure 1: An overview of the target outlining process and volume comparison The median Dice score for the CTV1/CTV2 was 0.98 and, of the voxels that differ (median 6.5 cc), 99.7% were covered with a 5 mm expansion.  Overall organs at risk (OAR) and target dosimetry were similar in the PTV1 and PTV2 plans.LegendFigure 2: The quantitative comparisons of target and dosimetry volumes Target  dosimetry metrics for PTV1 and PTV2 plansOrgans at risk metrics for PTV1 and PTV2 plansLegendFigure 3: Target and organ at risk dosimetry metrics for PTV1 and PTV2 plans  ProKnow DS along with Golden Rule enables flexible, efficient and effective RT plan batch analyses. Volume and dosimetric analyses included using the alternate plans 95% isodose as a structure for volume comparison.  Future work may consider a Delphi and a prospective study to inform clinical FET-PET-aided RT planing guidelines. ProKnow DSVarian Eclipse V16.1Golden RuleOrbit -RTProvided the 18F-FET PET scan is acquired within two weeks of the RT planning and a comprehensive approach is taken to CTV delineation, the timing of scan acquisition has minimal impact on the resulting RT plan.1)  Niyazi M, Andratschke N, Bendszus M, Chalmers AJ, Erridge SC, Galldiks N, et al. ESTRO-EANO guideline on target delineation and radiotherapy details for glioblastoma.Radiotherapy Oncol 2023;184:109663.

The Impact of Fluorine-18-fluoroethyltyrosine Positron Emission Tomography (F18-FET-PET) Scan Timing on Radiotherapy Planning in Newly Diagnosed Patients with Glioblastoma - A Planning Study

https://researchmgt.monash.edu/ws/files/600978220/600532583.pdf

The Impact of Fluorine-18-fluoroethyltyrosine Positron Emission Tomography (F18-FET-PET) Scan Timing on Radiotherapy Planning in Newly Diagnosed Patients with Glioblastoma - A Planning Study

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