This paper presents the extremely low-voltage supply of the CMOS structure of a differential difference transconductance amplifier (DDTA). With a 0.3-volt supply voltage, the circuit offers rail-to-rail operational capability. The circuit is designed for low-frequency biomedical and sensor applications, and it consumes 357.4 nW of power. Based on two DDTAs and two grounded capacitors, a voltage-mode universal filter and quadrature oscillator are presented as applications. The universal filter possesses high-input impedance and electronic tuning ability of the natural frequency in the range of tens up to hundreds of Hz. The total harmonic distortion (THD) for the band-pass filter was 0.5% for 100 mV(pp) @ 84.47 Hz input voltage. The slight modification of the filter yields a quadrature oscillator. The condition and the frequency of oscillation are orthogonally controllable. The frequency of oscillation can also be controlled electronically. The THD for a 67 Hz oscillation frequency was around 1.2%. The circuit is designed and simulated in a Cadence environment using 130 nm CMOS technology from United Microelectronics Corporation (UMC). The simulation results confirm the performance of the designed circuits
