Heavily Treatment-Experienced Persons Living with HIV Currently in Care in Italy: characteristics, Risk Factors, and Therapeutic Options - the ICONA Foundation Cohort study
OBJECTIVES: Heavily Treatment-Experienced (HTE) People Living with HIV (PLWH) pose unique challenges due to limited antiretroviral treatment (ART) options. Our study aimed to investigate the prevalence and features of HTE individuals followed up inthe ICONA cohort as of December 31, 2021. METHODS: HTE were defined based on meeting specific conditions concerning their current ART and their ART history up to December 31, 2021.Descriptive statistics were performed by HTE status. Regression analyses explored factors associated with becoming HTE based on pre-ART patients' characteristics. Cluster dendrogram analysis provided insights into subgroups with inadequate responses based on CD4 counts and viral load (VL) trajectories Results: Among the 8,758 PLWH actively followed in our cohort, 163 individuals(1.9%),mainly female, younger, Italian, and infected through heterosexual contact,met the HTE criteria. A lower CD4 count at ART initiation (OR 1.60 per 100 cells/mmc lower CD4, 95% CI 1.06-2.41, p=0.03) and HCV Ab positivity (OR 1.90, 95% CI 1.16-3.11, p=0.01) were associated with higher HTE risk. Thirty PLWH exhibited ongoing immune-virological failure (18% of the HTE subgroup and 0.003% of the total population). Thirty PLWH exhibited ongoing immune-virological failure (i.e. with a current CD4 count200 copies/mL). A cluster analysis identified 13 (43%) with a current CD4 count<200 cells/mmc. Also, notably, 19/30 (63%) had major acquired resistance-associated mutations to at least one ARV drug class. CONCLUSIONS: HTE is rare in our cohort and tends to co-exist with major resistance mutations. A focused investigation into treatment history and immuno-virological response is warranted, particularly given the availability of new ARV drugs
