Allergic inflammation triggers dyslipidemia via IgG signalling

Abstract

Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may precede or exacerbate other pathologies. In this regard, allergy has been associated to metabolic disorders and with a higher risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood.R.J.-­ S.´s laboratory has received support from the Severo Ochoa Program (AEI/SEV-­2017-­0712; Spain), FSE/FEDER through the Instituto de Salud Carlos III (ISCIII; CP20/00043; PI22/00236; Spain), The Nutricia Research Foundation (NRF-2021-­13; The Netherlands), New Frontiers in Research Fund (NFRFE-­ 2019-­ 00083; Canada) and SEAIC (BECA20A9; Spain). F.S.-­ M. reports grants from Ministerio de Ciencia e Innovación (MICIN; PID2020-­ 120412RB-­ I00; Spain), and Comunidad de Madrid (INTEGRAMUNE, P2022/BMD7209; Spain). V.E. obtained support from the ISCIII (PI21/00158; Spain). N.F.-­ G. and I.R.-­ F. received a Formación de Profesorado Universitario grant (FPU16/03953 and FPU20/05176, respectively) from Ministerio de Universidades (Spain). N.F.-­ G. and L.M.-­ S. are supported by the INVESTIGO Program of the Comunidad de Madrid and Ministerio de Trabajo y Economía Social, Servicio Público de Empleo (SEPE), respectively, which is funded by “Plan de Recuperación, Transformación y Resiliencia” and “NextGenerationEU” of the European Union (09-­ PIN1-­ 00015.6/2022 and 2022-­ C23.I01.P03.S0020-­ 0000031). R.C.-­ G. is supported by Ayudas para con- tratos Juan de la Cierva-­ formación 2021 (FJC2021-­ 047282-­ I) from MICIN (Spain). C.L.-­ S. and E.N.-­ B. are supported by a Río Hortega (CM23/0019) and a Sara Borrell grant (CD23/00125), respectively, from ISCIII. P.M.is supported by MICIN-­ ISCIII-­ Fondo de Investigación Sanitaria (PI22/01759; PMPTA22/00090-BIOCARDIOTOX) and Comunidad de Madrid (P2022/BMD-­ 7209-INTEGRAMUNE-­CM; Spain) CNIC is a Severo Ochoa Center of Excellence (grant CEX2020-­ 001041-­ Sfunded by MICIN/ AEI/10.13039/501100011033).Peer reviewe