Calcineurin A-β1 (CnAβ1) is a noncanonical isoform of calcium-
based protein phosphatase Calcineurin with a unique C-terminal
domain that sets it apart from the canonical forms and results in
completely different functions and interactions, sometimes
directly opposing the effect of standard Cn. The actual roles of
CnAβ1 in different tissues have been barely studied so far,
however, and any processes it could be part of in the brain in
particular are currently unknown. Our preliminary data suggests
CnAβ1 could play a role in neural stem cell (NSC) regulation and
dynamics; as the natural capabilities for adult neurogenesis and
post-injury repair of the brain and its NSCs are limited, any
insight on these processes and the potential involvement of
CnAβ1 in them could provide new venues for therapeutic and
neuroengineering approaches, as they concern
neurodegenerative pathologies and cerebrovascular lesions.
Further research will be carried out with advanced 3D imaging
and tissue clearing techniques in order to verify and expand these
findings.This work has been funded by Instituto de Salud Carlos III
(ISCIII) through the projects DTS22/00030 co-funded by
the European Union, and PT20/00044 co‐funded by
European Regional Development Fund "A way to make Europe”. It has also been supported by Ministerio de
Ciencia e Innovación through the grant PLEC2022‐009235
funded by MCIN/AEI /10.13039/501100011033 and by
the “European Union NextGenerationEU/ PRTR”, and
through the grant PID2021-127033OB
C21/MCIN/AEI/10.13039/501100011033
