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脑胶质瘤免疫治疗研究进展
Authors
牟永告
Publication date
1 January 2020
Publisher
Editorial Office of Journal of Sun Yat-sen University
Abstract
神经胶质瘤是中枢神经系统中最常见的原发肿瘤,其中过半数是WHOIV级的胶质母细胞瘤,即使接受包括了手术、同步放化疗及辅助化疗的治疗,其中位生寸期仍只有14.2个月。免疫抑制是恶性胶质瘤的重要特征,逆转免疫抑制的免疫治疗仍然是近年来最有希望提高胶质瘤患者治疗效果的方式。本文综述了胶质瘤的免疫治疗进展,以及胶质瘤微环境中调节性T细胞(Treg)与糖皮质激素诱导的肿瘤坏死因子受体(GITR)的研究进展,希望为恶性胶质瘤的免疫治疗提供新的研究思路
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Last time updated on 15/10/2024