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E-选择素介导的大鼠脑缺血再灌注后继发炎症损伤的实验干预
Authors
曾进胜
李锐
+4 more
王彦莉
盛文利
许晓伟
黄如训
Publication date
1 January 2007
Publisher
Editorial Office of Journal of Sun Yat-sen University
Abstract
【目的】通过在大鼠脑缺血后再灌注期间使用左旋精氨酸干预黏附分子E-选择素的表达从而减轻炎症损伤。【方法】先后复制易卒中型肾血管性高血压大鼠(RHRSP)模型和右侧大脑中动脉缺血2h再灌注(MCAO/R)线栓模型(n=192),并设立MCAO假手术组(n=48)。入选MCAO大鼠随机分为3个组,分别于缺血早期给予左旋精氨酸(n=72)、右旋精氨酸(n=48)和等体积生理盐水(n=72)。测定缺血侧脑组织NO代谢物含量、MPO活性、间接免疫荧光染色和RT-PCR方法检测E-选择素表达。【结果】左旋精氨酸组缺血后至再灌注0、4和8h后NO代谢物含量(52±12、81±34、131±27)高于相应时间段的盐水组(43±14、40±17、105±39)和右旋精氨酸组(38±13、34±16、109±29)。左旋精氨酸组大鼠缺血及再灌注早期E-选择素表达及MPO活性低于右旋精氨酸组和盐水组。【结论】大鼠脑缺血早期使用左旋精氨酸可以增加缺血区域NO含量,减少缺血再灌注早期E-选择素的表达和中性粒细胞的浸润
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Last time updated on 16/10/2024