UK Biobank is an unparalleled resource of extensive health information from 500 000 individuals and with more than 400 peer-reviewed publications to date. The sampling population is volunteer-based and is not representative of the UK population. Investigators state that although the estimates of prevalence and incidence should be interpreted with caution, valid measures of association and estimates of causal effect can be more readily interpreted as they do “not require participants to be representative of the population at large”
