The research aimed to determine chemical and physical content of coffee powder combined with papaya seeds and Arabica coffee beans from West Sumba. This research method is an experiment using a Completely Randomized Design (CRD) with one factor. The treatment factors were papaya seed powder and Arabica coffee powder there are four treatments, and repeated 3 times, so there were 12 experimental units. The best research results were B4 treatment with a combination of 25% papaya seeds and 75% Arabica coffee beans with a caffeine content of 0.93%, water content of 1.17%, ash content of 2.82%, color preference of 4.33 categories, preference aroma 4.24 like categories, and taste preferences 4.12 like categories. The highest yield value (NH) shows the best treatment is B4 treatment with a total NH value of 0.60. Analysis of business feasibility in the best treatment with an RCR of 1.28. R/C Ratio 1 with selling price Rp. 11,500/Packaging 150g
