Casigliani, V.

Catani, C.

Cocca, G.

Mazzilli, Sara

Nicola, C

Ranieri, R.

Sebastiani, T.

Selva, P.

Stemat, A.

Tavosci, L.

English

Archivio istituzionale della Ricerca - Scuola Normale Superiore

13.H. Oral session: Screening and treatmentsFeasibility and acceptability in health centers ofscreening for chlamydia in deprived populationEmilie LobertreauE Lobertreau1, L Goethals2, M Oriol1, I Vincent3, E Amsallem11Disease and Public Health, National Center for Health ExaminationPrevention, Saint-Etienne, France2SNA-EPIS - EA4607 Laboratory, Jean Monnet University Saint-Etienne,Saint-Etienne, France3Prevention and Health Promotion, The French National Health InsuranceFund, Paris, FranceContact: emilie.lobertreau@cetaf.frIssue:The French Health Insurance (FHI) is in charge of thegovernance of 100 Health Examination Centers (HEC). HECprovide evidence-based interventions in prevention, focusedon deprived population. In France, Chlamydia trachomatis(Ct) infection is the most sexually transmitted infection,especially among young women.Description of the problem:To assess the feasibility of systematic screening Ct infection, inHEC, among 18-25 years women and 18-30 years men, with afocus on self-sampling. Pragmatics questions were: how theyouth accept the screening of Ct infection (especially the self-taken vaginal swabs)? Was the feasibility and Ct positivitysimilar between deprived and non-deprived population(according to the EPICES score)? A cross-sectional multicentersurvey was performed in 13 HEC in January 2018.Results:Screening was proposed to 1702 eligible young people (sexuallyactive and no recent Ct treatment). 90.3% [88.8-91.6] acceptedand participated: 44% women, 54% deprived people. Amongwomen, 76.8% [73.4-79.9] used self-taken vaginal swabs,others urinary tests. Rates did not differ according todeprivation (p = 0.96). Screening was performed in 1487people (96.7% for deprived vs 97.7% for non-deprivedpopulation, p = 0.258). Ct detection rate was 4.7% [3.7%-5.9%], significantly higher for deprived population (6.5% vs2.5%, p < 0.001).Lessons:The results demonstrated the feasibility of Ct screening in HECwith a good acceptance among youth even among youngdeprived. The performance rate of the test was similaraccording to deprivation. However, deprivation was associatedwith having a positive Ct result. This feasibility led to theimplementation of Ct screening in all HEC.Key messages: Chlamydia trachomatis screening can be easily implementedeven in deprived populations that accept and perform it aswell as non-deprived populations. Promoting access to Chlamydia trachomatis screening todeprived populations might contribute to reduce socialinequalities in health.Feasibility of HCV micro-elimination: HCV test andtreatment in two harm reduction services in MilanSara MazzilliS Mazzilli1,2, T Sebastiani3, V Casigliani1, G Cocca3, A Stemat4,C Nicola3, P Selva3, C Catani3, L Tavosci1, R Ranieri41Department of Translational Research and New Technologies, University ofPisa, Pisa, Italy2Scuola Normale Superiore, Pisa, Italy3Local Harm Reduction Servece, San Paolo University Hospital, Milan, Italy4Penitentiary Infectious Diseases Unit, San Paolo University Hospital, Milan,ItalyContact: sara.mazzill@gmail.comBackground:Most of Harm Reduction Service (HRS) users represent acrucial high-risk population for blood borne infections,including HCV. With the advent of new direct antiviralagents (DAAs), HCV micro-elimination in this setting hasbecome feasible. We evaluated HCV treatment cascade in twoHRSs located in Milan.Methods:We collected data on demographics, substance abuse history,HIV prevalence, HCV prevalence, testing and treatment on allregister HRS users on 1 January 2019. Data collection wasclosed on 1 January 2020.Results:A total of 881 HRS users (732M,149F) were included(median age: 45). The majority was addicted to heroin67.5% (595), 24.1%(212) to cocaine, 5.3%(47) to THC and3.1%(27) to other substances. The 28.0%(247/881) reportedcurrent or prior judiciary problems, 168/881(19.1%) wereunder psychiatric treatment. HCV serological screening(HCVAb) was performed for 587/881(66.7%), 113/881(12.8%) were in process, 2/881(0.2%) refused, 179/881(20.3%) were not HRS user anymore. 364/587(62%)resulted HCVAb positive, of whom 288(79.1%) were testedfor HCV RNA. Among them 123/324(37.9%) were positive,165/324(50.9%) were negative. Among HCVAb positive,116/364(31.9%) were tested for HIV and 92(79.3%) resultedHIV positive. Among HCV RNA positive 92/123(74.8%)were initiated on DAAs treatment. Compliance to treatmentwas high; one treatment failure was registered. Individualstested for HCV and HCVAb positive people had an averageage significantly higher than the individuals not tested andHCVAb negative people (p < 0.001). Heroin user had ahigher likelihood of being tested both for HCVAb and forHCV RNA and of being positive to the HCVAb test(p < 0.001).Conclusions:Our study demonstrate that it is feasible to achieve goodefficacy and compliance for HCV treatment among peoplewho use drugs when decentralising treatment to HRS. Toachieve the viral hepatitis elimination agenda goals, HRS-basedmodel of treatment provision needs to be implemented atlarger scale.Key messages: Decentralising HCV test and treatment to harm reductionservices is an effective strategy to achieve HCV micro-elimination among people who use drugs. Young people and people who are addicted to othersubstance than heroin resulted more difficult to link toHCV care through the harm reduction services. Theyrequire tailored intervention.The 8-item Morisky medication adherence scale:validation of a Portuguese version in HIV patientsAna AguiarA Aguiar1, C Piñeiro2, R Serrão2, R Duarte1,3,41EPIUnit - Epidemiology Research Unit, Instituto de Saúde Pública daUniversidade do Porto, Porto, Portugal2Serviço de Doenças Infecciosas, Centro Hospitalar Universitário de SãoJoão, Porto, Portugal3Public Health Science and Medical Education Department, Faculty ofMedicine, University of Porto, Porto, Portugal4National Reference Centre for MDR-TB, Hospital Centre Vila Nova de Gaia,Vila Nova de Gaia, PortugalContact: anaaguiar590@gmail.comBackground:Antiretroviral therapy (ART) has the most effective treatmentfor people with HIV, but its effectiveness depends on theindividual medication adherence. Morisky MedicationAdherence Scale (MMAS-8) is one of the most widely usedscales to assess patient adherence. Thus, we aimed to validate aPortuguese version of MMAS-8 and determine its psycho-metric properties in HIV positive patients.v246 European Journal of Public Health, Volume 30 Supplement 5, 2020Downloaded from https://academic.oup.com/eurpub/article/30/Supplement_5/ckaa165.668/5915933 by Scuola Normale Superiore Biblioteca user on 14 November 2023

Feasibility of HCV micro-elimination: HCV test and treatment in two harm reduction services in Milan

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Feasibility of HCV micro-elimination: HCV test and treatment in two harm reduction services in Milan

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