The aim of this project is to evaluate the influence of bioactive compounds contained in raw and processed plant-based foods, and their industrial processing by-products on the immune landscape and homeostasis of the gut affected by chronic inflammation

Carlo Ennio Michele Pucillo

Maria Cristina Nicoli

Marilisa Alongi

Umberto Lanza

English

Archivio istituzionale della ricerca - Università degli Studi di Udine

AimsReferencesExpected activitiesBackgroundExperimental approachFood and food bioactive fighting chronic inflammationUmberto Lanza (lanza.umberto@spes.uniud.it)Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, ItalyTutors: Prof. Maria Cristina Nicoli; Prof. Carlo Ennio Michele Pucillo; Co-Tutor: Ph.D. Marilisa AlongiExpected results1. Furman, D. et al. (2019) ‘Chronic inflammation in the etiology of disease across the life span’, Nature Medicine, 25(12), pp. 1822–1832. doi:10.1038/s41591-019-0675-0.2. Zhang, Y.Z. and Li, Y.Y. (2014) ‘Inflammatory bowel disease: Pathogenesis’,World Journal of Gastroenterology, 20(1), pp. 91–99.doi:10.3748/wjg.v20.i1.91.3. Marion-Letellier, R., Savoye, G. and Ghosh, S. (2016) ‘IBD: In food we trust’,Journal of Crohn’s and Colitis, 10(11), pp. 1351–1361. doi:10.1093/ecco-jcc/jjw106.4. Roda, G. et al. (2020) ‘Crohn’s disease’, Nature Reviews Disease Primers,6(1). doi:10.1038/s41572-020-0156-2.5. Cömert, E. D., & Gökmen, V. (2017). Antioxidants Bound to an Insoluble FoodMatrix: Their Analysis, Regeneration Behavior, and Physiological Importance.Comprehensive Reviews in Food Science and Food Safety, 16(3), 382–399.6. Brodkorb, A., 2019. INFOGEST static in vitro simulation of gastrointestinalfood digestion. Nature Protocols, 14(4), pp.991–1014.Activities 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24A1) Literature reviewA2) Preliminary testsA3) Design of bioactive-containing model systemA4) In vitro digestionA5) Analysis of the bioaccessibility and bioavailability of bioactive compoundsA6) Experimental model developmentA7) Immunologic analysisA8) Company periodA9) Paper writing and thesis development• Gain knowledge on the fate of bioactives related to thefood composition and structure;• Development of technological strategies to optimizebioaccessibility and bioavailability of dietary bioactivesin fruit derivates;• Lay the foundations for the management of gutchronic inflammation through the diet;Model systems containing quercetin with growing complexity in composition and structureIn vitro digestion6 and bioaccessibility evaluationIn vitro bioavailability evaluationusing Caco-2 monolayer cell culturesInvestigation of the mechanistic effects on inflammation and immune landscape in a model system• Chronic inflammation contributes to the onset of several diseases1. Inflammatory bowel disease (IBD) is a clear example of a conditiongenerated by the establishment of chronic inflammation in the intestine2.• A diet rich in fruit and vegetables, by virtue of their content in bioactive compounds, was proved to exert health-promoting effects and tobe protective against chronic inflammation3,4.• However, no linear cause-effect mechanism behind food bioactive compounds positive effect has been proved. A reason can beattributed to the fact that present studies don’t take into consideration the complexity of the food matrix in relation to the fate of thebioactive compounds in terms of bioaccessibility and bioavailability5.Investigate the fate of bioactive compounds bioaccessibility and bioavailability as a function of food composition and structure. To thispurpose, model systems with increasing complexity in terms of composition and structure, mimicking different fruit derivates will beconsidered.Food Processing Digestion Physiological effect

Food and food bioactive fighting chronic inflammation

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Food and food bioactive fighting chronic inflammation

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