The results here described are part of a wider experimental plan aimed at studying the fate of quercetin contained in model systems simulating apple or its derivatives during the gastrointestinal process. To this purpose, the effect of in-vitro digestion on quercetin antioxidant activity was assessed. Quercetin’s effect on the inhibition of intestinal α-glucosidase in a colorectal adenocarcinoma cell line Caco-2 was also investigate