Since their origins, human societies have integrated into the natural environment, where social metabolism that
identified the interactions between society and nature was established. This social metabolism enables the flows
of energy and materials between social and natural environments to be analyzed and quantified. However, in
the last century, many societies have undergone a transformation from an agricultural to an industrial system.
Thus, labour, as a generator of economic capital through the supply chain, has provoked a loss of natural and
social capital, especially in emerging economies, thereby generating the metabolic rift. This situation can be mitigated
and reversed through a circular economy, the use of digital and technological enablers of Industry 4.0 and
the incorporation of an organizational enabler such as the holonic paradigm. The integration of these enablers
has given rise to the development of the cyber-physical holon, which incorporates inherently sustainable concepts
and allows the analysis of distributed complex systems. This paper proposes a holonic framework for multiscale
and multilevel Adaptive and Integrated Sustainable Supply Chain Management (AISSCM). This framework
supports a smart connected social metabolism integrated within the natural environment and oriented towards
mitigation and reversal of the metabolic rift, through the processes of adaptation and integration to enable the
co-evolution of the supply chain within the environment. The framework developed is applied to a family of
products through their sustainable supply chain based on circularity. This proposal is developed to enable the
necessary transition towards sustainable societies
