Comparative efficacy and safety of mineralocorticoid receptor antagonists in patients with heart failure and reduced ejection fraction: a systematic review and network meta-analysis

Abstract

The primary objectives of the present study will be to assess the comparative efficacy and safety of different mineralocortiocoid receptor antagonists (MRAs) on hard and surrogate outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and a left ventricular ejection fraction (LVEF) of no more than 45%