The Midlife in the United States study (MIDUS) is a longitudinal national study of adults in the United States that began in 1995. MIDUS consists of several projects, including Survey, Daily Diary, Cognitive, Biomarkers, and Neuroscience projects. The original MIDUS sample was assessed between 1995-1997 (MIDUS 1), again between 2004-2009 (MIDUS 2), and again starting in 2013 (data collection ongoing; MIDUS 3). To replenish the original sample, new participants were added to the protocol between 2011-2014 (MIDUS Refresher). This OSF page is intended to serve as the basis for several projects relating to the MIDUS Refresher neuroscience project functional MRI data. We outline here the details of how MIDUS Refresher fMRI data were collected, cleaned, and processed by our group. Parts of the MIDUS Refresher fMRI data have already been analyzed and some hypotheses have already been tested by others in our group and will be noted when relevant. A clear delineation of what hypotheses have been tested and which have yet to be tested will be included when necessary