Drone-based photogrammetry typically requires the task of georeferencing aerial images by detecting the center of Ground Control Points (GCPs) placed in the field. Since this is a very labor-intensive task, it could benefit greatly from automation. In this study, we explore the extent to which traditional computer vision approaches can be generalized to deal with variability in real-world drone data sets and focus on training different residual neural networks (ResNet) to improve generalization. The models were trained to detect single keypoints of fixed-sized image tiles with a historic collection of drone-based Red–Green–Blue (RGB) images with black and white GCP markers in which the center was manually labeled by experienced photogrammetry operators. Different depths of ResNets and various hyperparameters (learning rate, batch size) were tested. The best results reached sub-pixel accuracy with a mean absolute error of 0.586. The paper demonstrates that this approach to drone-based mapping is a promising and effective way to reduce the human workload required for georeferencing aerial images