Formulation and Evaluation of Instant Dissolving Film of a Poorly Soluble Drug Cilnidipine

Abstract

The chemical formula in question is classified as a calcium antagonist, which includes cilnidipine (also known as dihydropyridine) as one of its component parts. This is accomplished through a process known as L-type calcium channel blockage, which prevents calcium from entering the capillaries and so accomplishes the desired effect. The consequence of this is a decrease in blood pressure. Intravenous administration of the medicine results in a higher level of bioavailability compared to oral administration of the drug in tablet form. This is due to the diminished solubility of the substance in water. Propylene glycol and PEG 400 were combined to create a polymer that lacked stickiness and hardness. The drug's solubility and release are greatly enhanced when inclusion complexes are made using cyclodextrin. Research on PEG 400 and propylene glycol drug release in vitro examined a number of independent factors, including pH, thickness, weight uniformity, percent drug content, folding endurance, disintegration time, and percent drug