Background: Grape-seed oil has diverse biological functions and is beneficial in treating metabolic complications, such as metabolic syndrome, obesity, diabetes, and dyslipidemia. The purpose of this study was to investigate the anti-hyperglycemic, anti-dyslipidemic, and anti-inflammatory effects of Grape-seed oil in diabetic rats. Materials and methods: 16 streptozotocin-induced diabetic Wistar rats were used in this study. Diabetic rats were randomly allocated to either of two groups (n = 8): diabetic rats treated with grape-seed oil or diabetic control. Grape-seed oil (GSO) (25 mg/kg BW) was administered orally for 40 days, and at the end, blood samples were taken directly from the heart. Results: Diabetic rats treated with oil compared to control diabetic rats demonstrated a significant (p = 0.001) decline in serum glucose concentration. High plasma concentrations of TG, LDL, and VLDL were reduced (p = 0.001, p = 0.001, p = 0.001, respectively). Surprisingly, between inflammatory markers, TNF-α was significantly (p = 0.02) increased. Furthermore, GSO-treated diabetic rats experienced a significant (p = 0.014) weight gain during the study. However, total cholesterol, HDL, and CRP levels did not change significantly. Conclusion: Treatment with grape-seed oil ameliorated dyslipidemia and hyperglycemia in diabetic rats. However, further investigations in peculiar clinical studies are required.</p
