C-Reactive Protein (CRP) is a marker to aid in diagnosing sepsis. Currently, there are not many studies about the
comparison of CRP levels in sepsis patients with a variety of instruments and methods. This study aimed to analyze
differences of CRP results using Particle Enhanced Turbidimetric Immunoassay (PETIA), Sandwich Immunodetection and
Reflectometry Immunoassay, and to compare the characteristics of the instruments based on their specifications and
practicality. The study used a total of 65 serum of sepsis patients who fulfilled the qSOFA criteria and were treated in the
Emergency Department, Intensive Observation Room, Intensive Care Unit (ICU) and Internal Medicine Wards of the Dr.
Soetomo Hospital Surabaya from May to September 2018. All samples were measured the CRP levels measured using the
three methods. There were significant differences of CRP levels between the PETIA and Reflectometry immunoassay
methods (p=0.003), suggesting a supportive role of both methods. There was no significant difference of CRP levels
between PETIA and Sandwich Immunodetection (p=0.172) as well as Reflectometry immunoassay and Sandwich
Immunodetection (p=0.251). The selection of instruments and methods for CRP examination must be adjusted to
laboratory needs and facilities
