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Busch, David R.

Cheruku, Sreekanth

Choi, Christopher

Dave, Siddharth

Durduran, Turgut

Lahsaei, Peiman

Olson, DaiWai

Quiroga, Andres

English

Engineering Conferences International

A LOW-COST, COMPACT DEVICE FOR MONITORING TISSUE OXYGEN CONSUMPTION USING SPECKLE CONTRAST OPTICAL SPECTROSCOPY  Andres Quiroga, Manish Verma, Faruk Beslija, Lisa Kobayashi Frisk, Sumana Chetia, Daniel Senciales, ICFO – Institut de Ciències Fotòniques, Spain andres.quiroga@icfo.eu Siddharth Dave, Dept of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Texas Sreekanth Cheruku, Dept of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Texas  Christopher Choi, Dept of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Texas  Peiman Lahsaei, Dept of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Texas DaiWai Olson, Dept of Neurology, University of Texas Southwestern Medical Center, Texas David R. Busch, Depts. of Anesthesiology & Pain Management, Neurology, and Biomedical Engineering, Texas Turgut Durduran, ICFO – Institut de Ciències Fotòniques, Institució Catalana de Recerca i Estudis Avançats (ICREA), Spain  Key Words: speckle contrast optical spectroscopy, microvascular blood flow, tissue oxygen saturation, vascular occlusion tests.  Accurate assessment of tissue oxygen metabolism is crucial for optimizing therapies and detecting disorders. We present a new approach using speckle contrast spectroscopy (SCOS) to simultaneously measure blood flow (BF) and tissue oxygen saturation (StO2). SCOS utilizes the speckle pattern generated by coherent light interacting with biological tissue to assess blood flow dynamics through changes in speckle contrast [1,2]. By capturing speckle intensity at different distances and wavelengths, we are able to also estimate StO2.   The multidistance and multiwavelength SCOS (MMSCOS) approach allows the real-time, non-invasive, and depth-resolved measurements of BF and StO2 in a compact (13x22x30 cm), low-cost (< €5000) device. The MMSCOS system (Figure 1a) also incorporates an optical probe (Figure 2b) for assessment of tissue hemodynamics, an automated tourniquet (Figure 1c) for vascular occlusion tests (for the assessment of endothelial function) and a pulse oximeter (Figure 1d) for real-time monitoring of peripheral arterial oxygenation, heart rate, and perfusion index. The use of commercial off-the-shelf (COTS) components such as laser diodes, CMOS cameras, Arduino family microcontrollers allowed us to reduce cost to practical levels for mass-deployment without a significant loss of precision and accuracy. We present the system design and analyze the benefits of MMSCOS, validating its performance through phantom measurements. In vivo measurements were also conducted to evaluate accuracy and precision using our standardized protocols over a large range of BF and StO2 values ranging from healthy baseline to ischemic/hypoxic levels to hyperemic ones. The inclusion of the tourniquet and the pulse-oximeter allowed us to automatize all processes, increase the clinical usability of the system and address the long-standing standardization problem hindering the use of vascular occlusion tests in clinical studies. Finally, we will present the results of the on-going clinical study on critical-care patients.  Primary support from US National Institutes of Health National Institute Biomedical Imaging and Bioengineering (R21 EB031261).  [1] C. P. Valdes, H. M. Varma, A. K. Kristoffersen, T. Dragojevic, J. P. Culver, and T. Durduran, “Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue,” Biomed. Opt. Express, BOE, vol. 5, no. 8, pp. 2769–2784, Aug. 2014, doi: 10.1364/BOE.5.002769. [2] T. Durduran et al., “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Optics Letters, vol. 29, no. 15, p. 1766, Aug. 2004, doi: 10.1364/OL.29.001766. Figure 1: a) MMSCOS device for monitoring BFI and StO2 simultaneously. Include a b) optical probe, c) arm cuff, and, d) pulse oximeter.       

A low-cost, compact device for monitoring tissue oxygen consumption using speckle contrast optical spectroscopy

https://dc.engconfintl.org/cgi/viewcontent.cgi?filename=0&article=1040&context=optics_2023&type=additional

A low-cost, compact device for monitoring tissue oxygen consumption using speckle contrast optical spectroscopy

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Engineering Conferences International