Columbia Univ., New York (USA). Coll. of Physicians and Surgeons
Abstract
From effects of neutron irradiation upon cell function; Neuherberg, F. R. Germany (20 Oct 1973). Sprague-Dawley female rats, 61 to 63 days of age, were given a single dose of either 0.10, 0.40, 1.6, or 6.4 rads of 0.43-MeV neutrons, or 28, 56, or 85 rads of 250-kVp x rays, or no radiation in a single experiment. The interim results, either in terms of percent of rats with mammary neoplasia or mean number of mammary neoplasms per rat, at the end of 14 months after irradiation, indicate that 0.10 to 0.40 neutron rads was followed by a mammary neoplastic response much like that following 28 xray rads. The mammary neoplastic response to either 6.4 neutron rads or 56 to 85 x-ray rads was similar. Thus the RBE for neutrons for the induction of mammary neoplasia in the SpragueDawley rat is much larger at low neutron doses than at high doses. (auth
