Beaton DR

Docherty J

Jenkins A

Lu L

Morris AJ

Nicholson BD

Rogers P

Rosch T

Rutter MD

Sharp L

Thoufeeq M

Trudgill NJ

\ua9 Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.Objective: This national analysis aimed to calculate the diagnostic yield from gastroscopy for common symptoms, guiding improved resource utilisation. Design: A cross-sectional study was conducted of diagnostic gastroscopies between 1 March 2019 and 29 February 2020 using the UK National Endoscopy Database. Mixed-effect logistic regression models were used, incorporating random (endoscopist) and fixed (symptoms, age and sex) effects on two dependent variables (endoscopic cancer; Barrett\u27s oesophagus (BO) diagnosis). Adjusted positive predictive values (aPPVs) were calculated. Results: 382 370 diagnostic gastroscopies were analysed; 30.4% were performed in patients aged &lt;50 and 57.7% on female patients. The overall unadjusted PPV for cancer was 1.0% (males 1.7%; females 0.6%, p&lt;0.01). Other major pathology was found in 9.1% of procedures, whereas 89.9% reported only normal findings or minor pathology (92.5% in females; 94.6% in patients &lt;50). Highest cancer aPPVs were reached in the over 50s (1.3%), in those with dysphagia (3.0%) or weight loss plus another symptom (1.4%). Cancer aPPVs for all other symptoms were below 1%, and for those under 50, remained below 1% regardless of symptom. Overall, 73.7% of gastroscopies were carried out in patient groups where aPPV cancer was &lt;1%. The overall unadjusted PPV for BO was 4.1% (males 6.1%; females 2.7%, p&lt;0.01). The aPPV for BO for reflux was 5.8% and ranged from 3.2% to 4.0% for other symptoms. Conclusions: Cancer yield was highest in elderly male patients, and those over 50 with dysphagia. Three-quarters of all gastroscopies were performed on patients whose cancer risk was &lt;1%, suggesting inefficient resource utilisation

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Diagnostic yield from symptomatic gastroscopy in the UK: British Society of Gastroenterology analysis using data from the National Endoscopy Database

Diagnostic yield from symptomatic gastroscopy in the UK: British Society of Gastroenterology analysis using data from the National Endoscopy Database

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