The new molecules in the form of microspheres 89Y2O3 obtained by modified INCT sol-gel method for liver cancer treatment

Abstract

In the Sol-Gel Laboratory (INCT) on the basis many years of experience in the preparation new generation of ceramic materials has been taken study for preparation microspheres Y2O3 to treatment hepatic malignancies cancer. Using a combination of patented processes (INCT Process, patent PL-83484 and Complex Sol-Gel Process-CSGP, patent PL-172618) in one method for the production of spherical particles with diameters 10 to 100μm obtained 89Y2O3 microspheres (decision to grant a patent by the Polish Patent Office of November 19, 2014 for patent application P-394645 in 2011). Microspheres after fractionating were study to physicochemical properties and were tested stability in the environment physiological saline, serum and blood. In order to obtain the properties of the radiopharmaceutical 89Y2O3 microspheres were irradiated in the reactor Maria in the reaction 89Y (n, γ) 90Y