In order to effectively cultivate applied pharmaceutical talents, aiming at the current teaching situation of organic chemistry, the basic course of pharmaceutical specialty, including the problems of curriculum setting, experimental teaching, and the integration of classroom and professional knowledge, it is proposed to overcome the problem of curriculum setting by combining "online+offline" in teaching. It should overcome the problems in experimental teaching with the help of virtual simulation platform. By cultivating students’ organic chemistry thinking and paying attention to the integration of subject and professional knowledge, students’ recognition of organic chemistry course can be improved, and the quality of training can be improved