<p>The agri-food industry generates around 50% of global waste, of which only 36% is recycled, although the potential recovery could be as high as 60%. These residual streams can be used as feedstock for the bio-based industry (BBI), provided that the composition, logistics and volume are carefully analysed. Within the framework of the European Model2Bio project (H2020-BBI-JTI-2019. No 887191), the authors are developing a Decision Support System (DSS) tool for the management of residual streams produced in agrifood companies. This will be an innovative concept that using predictive models will be able to select the best routes for valorising these streams considering their composition, seasonality, and industry location, among other factors. This innovative MODEL2BIO-DSS tool is based on the interconnection of three complementary elements (simulation module, optimisation algorithm and LCA module). </p><p>The main advantage of the tool is the possibility of giving a holistic solution or prioritisation. Although there are many commercial programs for the simulation of industrial processes, these are mainly based on the analysis of specific facilities, and not on broader analyses with various industries, in which logistics plays a key role. Model2Bio will simulate the entire value chain providing recommendations from a holistic perspective (technical, economic, environmental and social), with the prioritisation of the valorisation possibilities through technical-economic criteria and the final decision through holistic criteria. Within the framework of the Model2Bio project, the tool is being tested in 3 European areas (Spain, Greece, Belgium) with the aim of analysing different management systems, with different degrees of development of valorisation technologies. To show the potential of this new concept for waste management, the final work will present the analysis and optimisation of the agri-food residual streams valorisation in La Rioja (Spain) carried out with the Model2Bio-DSS tool. In this analysis, a comparison of the current agri-food residual streams management and the optimised management will be presented, considering economic and holistic aspects. </p>