The ability to inject “spent” geothermal brine may be a critical and perhaps limited factor in the development of fluid-dominated geothermal resources. In order to understand and evaluate changes in formation permeability and porosity at depth as a result of injection of brine effluents, experiments were carried out (70°-90°C at 10.3 MPa confining pressure) in conjunction with the ongoing brine chemistry and materials evaluation effort at the Lawrence Livermore Laboratory Field Test Station located in the Salton Sea Geothermal Field, Imperial Valley, California. In summary, the data portrayed in Figure 1 indicate that large permeability losses occurred in Kayenta sandstone (porosity, 20.7 ± 1.66%) when unfiltered, untreated Magmamax brine and filtered, acidified Magmamax brine were the permeating fluids. In the former case, permeability decline was due to the accumulation of a thick filter cake on the top face of the core sample which was composed of amorphous silica and iron. In the latter situation, loss of permeability was caused by the precipitation of amorphous silica and generation of large quantities of calcite particles from the dissolution of the matrix cement. The experimental results thus show that if the Salton Sea Geothermal Field were composed of porous sedimentary formations similar to Kayenta sandstone, long-term injection of unmodified Magmamax brine is not feasible. In the case of acidified brine, most of the permeability decline may result from the mobilization of calcite. Additional experiments will be carried out in the future at lower flow rates to test the possibility of long-term injection of filtered, acidified geothermal brine. 6 refs., 1 tab., 1 fig