The aim of this study is to compare perioperative parameters of laparoscopic partial nephrectomy and open
partial nephrectomy in renal tumor management, and to evaluate the effect of using novel method of indocyanine green
navigation in segmental ischemia on these parameters. The prospective study included 455 patients (89 laparoscopic
partial nephrectomies, 366 open partial nephrectomies). Sub-groups (n=39, 32, 18) in Laparoscopic partial nephrectomy
employed diverse ischemia techniques, including full warm ischemia, segmental ischemia with indocyanine green
navigation and segmental ischemia without navigation. Parameters assessed encompassed estimated blood loss, operative time, warm ischemia time, and changes in estimated glomerular filtration rate. Covariate-balancing propensity
scores ensured homogeneity. Statistical analysis included the Wilcoxon signed-rank test, for two matched groups. Twosided p-values were reported for all statistical tests, a p-value <0.05 was considered to be statistically significant. The
findings of the conducted research indicate that open partial nephrectomy has revealed significant differences in
estimated blood loss, operative time, and warm ischemia time, in favor of open partial nephrectomy. Laparoscopic partial
nephrectomy offers advantages in preserving renal function and minimizing estimated Glomerular Filtration Rate decline
compared to open partial nephrectomy. The utilization indocyanine green navigation, facilitates precise and limited
ischemia, contributing to enhanced preservation of renal function. Surgeons must weigh these considerations for optimal
renal tumor management