Balázs Dóra

Kredics László

Marik Tamás

Rozsnyói Ákos

Szekeres András

Tyagi Chetna

Vágvölgyi Csaba

English

University of Szeged

14  INVESTIGATING THE EFFECTS OF PEPTAIBOLS THROUGH STRUCTURE- AC-TIVITY RELATIONSHIPS Dóra Balázs1*, Tamás Marik2, Ákos Rozsnyói1, András Szekeres2, Csaba Vágvölgyi2, Chetna Tyagi2, László Kredics2 1Doctoral School of Biology, Faculty of Science and Informatics, University of Szeged, Szeged, HUNGARY, 2Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, HUNGARY *corresponding author: dora.balazs91@gmail.com  In terms of agriculture and biocontrol, the role of filamentous fungi from the genus Tricho-derma has been increasing in the recent years. Among the secondary metabolic products of Trichoderma species, peptaibols are of particular importance, and due to their characteristic properties, peptaibols may potentially be used in agriculture in the future. Peptaibols exert inhibitory effects against various plant pathogenic Gram-positive bacteria as well as fungal plant pathogens. Based on previous experiments, peptaibols may have the potential to support plant growth and provide protection against plant pathogenic microorganisms. In addition to laboratory tests of the purified peptaibol extracts, we can deepen our knowledge about the effects of peptaibols through in silico studies, such as accelerated molecular dynamics (aMD) simulations. In our experiments, the peptaibol production of 8 strains of Trichoderma species were deter-mined, and purified peptaibol extracts were examined through laboratory tests and modern molecular modeling tools. The peptaibol extracts were tested against commonly known 11 Gram-positive and Gram-negative bacterial strains, as well as two plant pathogenic fungal species. The minimum inhibitory concentration (MIC, mg ml-1) and effective concentration (EC, mg ml-1) values of the purified peptaibol extracts were determined and the results were compared with the characteristic properties of the most produced peptaibol sequences simu-lated by aMD. Correlations were studied through the investigation of structure-activity relationships (SARs) of peptaibols. By examining peptaibols from different aspects we can gain a wider insight into their bioactivity and promote their possible future application in crop protection and agriculture.    

Investigating the effects of peptaibols through structure - activity relationships : [abstract]

http://acta.bibl.u-szeged.hu/84134/1/wellmann_abstracts_2023_014.pdf

Investigating the effects of peptaibols through structure - activity relationships : [abstract]

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University of Szeged