Salivary Gland Tumors (SGTs) are a diverse group of neoplasms, with a wide range of histological subtypes, some of which can exhibit overlapping features. Amongst this group of tumors, Pleomorphic Adenoma (PA) and Mucoepidermoid Carcinoma (MEC) stand out as prevalent entities originating from the salivary glands. The accurate differentiation between these two entities is crucial for treatment planning, as it influences decisions regarding the extent of surgical resection. Because of the overlapping histopathological features, it is difficult to differentiate these two lesions with the help of conventional Hematoxylin & Eosin (H& E). The evaluation of Immunohistochemical (IHC) markers holds pivotal importance in diagnosing salivary gland tumors, offering valuable insights into their molecular and cellular characteristics. The application of IHC markers assumes paramount importance in the precise diagnosis of MEC and PA within the context of salivary gland tumors. The study aimed to assess the effectiveness of immunobiomarkers in differentiation between mucoepidermoid carcinoma and pleomorphic adenoma
