Antidiabetic effects of Setaria italica seeds aqueous extract in STZ induced diabetic rats. A Histopathological study

Abstract

<p>Background: Setaria italica is commonly known as Foxtail millet. In India it is chiefly cultivated in Andhra Pradesh, Telangana and Tamil Nādu. It can be taken as sweet or savoury food in all ways that rice is used. Due to the presence of high fibre content, it is suggested as a food for diabetic patients. Objectives: To evaluate the protective effects of SISAE on STZ induced diabetic rats. Materials and Methods: Histopathology of pancreas, liver, and kidney tissues of the STZ induced diabetic rats after treatment with SISAE for 30 days was studied.  Results: In histopathological examination, Stained sections of pancreas of diabetic untreated rats showed destruction of beta cells with lymphocytic infiltrations and atrophy was appeared. But treatment with SISAE showed regenerative changes in the pancreas tissue architecture. Stained sections of the diabetic untreated rats showed degenerative liver with severe congestion of central vein, haemorrhage in the sinusoidal spaces with hazy nucleus. But, treatment with SISAE in diabetic rats showed improvement in histological structure of liver sections of diabetic rats with normal appearance of the liver lobules. And kidney sections of diabetic untreated rats showed tubular damage and haemorrhage. But after treatment with SISAE damage of the kidney tissue was controlled.  Conclusion: The results from this study confirms that SISAE successfully ameliorated the degenerative changes in the histology of the pancreas, liver and kidney tissues of the STZ induced diabetic rats.</p&gt