SPIRIT schedule of enrolment, interventions, and assessments.

Abstract

1 = for arm 1 (oral steroid), 2 = for arm 2 (intratympanic injection), 3 = for arm 3 (combined treatment). # Optional weekly testing, for participants who have internet access. * should be performed within three days prior to commencement of treatment. **recommended to be performed on same day as pure tone audiogram or if not practicable within next working day. & Only persistent perforation of the tympanic membrane will be recorded at 12 weeks.</p