Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development

Abstract

Photoallergy, a unique form of skin sensitization induced by specific compounds underultraviolet irradiation, has traditionally been investigated using animals. However, the prohibition ofanimal testing for the assessment of cosmetic ingredients in Europe and other countries underscoresthe necessity for in vitro or in silico alternative methods. Currently, there are no validated methods forassessing photoallergy or photosensitization, presenting a significant challenge in the development ofnew cosmetic ingredients. This review examines the landscape of alternative methods for detectingphotosensitization, emphasizing recent publications, and considering the underlying principles ofthe different proposed assays.</p