Introduction: This study aims is to explore the relationship of serum glucose, triglyceride and total cholesterol levels and breast cancer (BC).Methods: We analyzed data in 100 women with confirmed BC and in the same number of age-matched disease-free controls. Cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) levels were estimated using chemiluminescent microparticle immunoassay technology. Glucose, triglyceride and total cholesterol levels were evaluated using dry chemistry method.Results: In this study no significant differences were found comparing glucose and total cholesterol levels in BC cases and controls. The adjusted ORs were 0.84 (95% CI: 0.48-1.49) and 0.62 (95% CI: 0.28-1.37) respectively. However, a significant inverse association between BC risk and increasing levels of triglycerides was observed, particularly at postmenopausal stage (OR= 0.32, 95%CI: 0.14-0.77). Based on CEA and CA15-3 levels measurement and BC duration, we showed that diabetes and lipid status did not influence the course of the malignancy.Conclusion: Our study highlights the absence of the effect of diabetes and dyslipidemia on the risk and progression of BC. Further prospective investigations are required to confirm this important issue
