국소 영역 가열을 통한 능동 약물 전달이 가능하도록 젤라틴이 코팅된 슈크로스 기반의 생분해성 마이크로로봇

Abstract

Microrobot, Magnetic actuation, Targeted drug delivery, Biodegradation, Con-trollable drug releaseNⅠ. INTRODUCTION 1 1.1 Microrobots for Minimally Invasive Cancer Therapy 1 1.1.1 Traditional methods of cancer therapy 1 1.1.2 Microrobots and actuation mechanisms 4 1.1.3 Magnetic actuation 9 1.1.4 Removal of microrobots after surgery 13 1.2 Research Trends 14 1.2.1 Drug delivery microrobots 14 1.2.2 Biocompatible and biodegradable microrobots 17 1.3 Objective of this Research 25 Ⅱ. MATERIALS AND FABRICATION 28 2.1 The SugarBot Materials 28 2.2 Fabrication of SugarBot 31 2.2.1 Sucrose composite fabrication 31 2.2.2 Sugar composite gelatin-coating process 33 Ⅲ. RESULTS AND DISCUSSION 35 3.1 Characterization of the Fabricated Gelatin-Coated SugarBot 35 3.1.1 Optimization of SugarBot fabrication 35 3.1.2 Biodegradability of SugarBot 39 3.1.3 Induction heating of SugarBot 42 3.1.4 Drug loading capacity of SugarBot 44 3.2 Magnetic Manipulation of SugarBot 45 3.3 Controlled Degradation of SugarBot 50 3.4 SugarBot In-Vitro Cell Viability Test 52 Ⅳ. CONCLUSION AND FUTURE WORK 59 4.1 Conclusions 59 4.2 Future Work 61 REFERENCES 63 요약문 73 Appendix 75MasterdCollectio