Income variables from the Brazilian population census (IBGE) are often used as proxies for the population’s socioeconomic level in spatial analyses of urban segregation, inequality and social exclusion. However, income variables are dependent on reference values (minimum wage) that change over time, which can be challenging for multitemporal analysis. This paper discusses this issue and proposes a methodology to adjust income data that allows a meaningful comparison between the datasets of two Census periods. The methodology was applied to five medium-sized cities of the state of São Paulo by adjusting income data from Census 2000 and 2010 according to the period’s inflation rates. The analysis shows that the methodology mitigates the comparability issues. Results better reflect the changes in population composition and in residential patterns of different income groups that took place over the 2000s in Brazil in medium-sized cities