Investigating of the physiopathology of colonic Diverticular Disease (DD), in that its missing knowledge characterization thwarts beneficial therapy, incrementing incidence and, consequently, clinical management cost. Even though it's a multifactorial pathology it's mainly characterized by transmural oxidative imbalance and consequently since the central role of the mitochondria for the metabolism and radicals production topic study is the elucidation of the mitochondrial pathogenetic functions in the different DD phenotypes. Ulteriorly, considering the scarce efficacy of the actual therapy mainly based on the administration of antibiotics and probiotics, we are also evaluating the potential role of antioxidants as therapeutic agents
