MilovancevMilanVetMedComparativePathologyCanine_SupplementaryMaterials.zip
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Abstract
Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the
histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin,
S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour
specimens by board-certified veterinary and medical pathologists, both blinded to the other’s interpretations.
Comparison between the veterinary and human diagnoses revealed a generally consistent pattern of interpretation
with few notable variations. Most tumours (13/32) were judged to display similar histomorphological
appearance to human low-grade spindle cell sarcomas, appearing non-distinctive and morphologically of a
fibroblastic/myofibroblastic type. Five canine cases resembled human liposarcoma, but with atypical
desmin-positive epithelioid cells present. Five canine cases resembled human spindle cell sarcoma with myxoid
features and two additional cases resembled human myxofibrosarcoma. Seven canine cases were noted to
resemble human undifferentiated sarcoma. Findings in the present study demonstrate that canine STSs display
histological and immunohistochemical features similar to their human equivalents. Because of these cross-species
similarities, a particular opportunity exists to understand the biology and treatment of human STS
by potentially including dogs as clinical models.Keywords: soft tissue sarcoma, man, comparative pathology, do