D. Gastaldi

De Cet

E. Verne'

F. Baino

G. Orlygsson

L. D’Andrea

P. Vena

English

PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino)

11 February 2024POLITECNICO DI TORINORepository ISTITUZIONALEIn silico characterization of micro-CT based bioactive glass-ceramic scaffolds / D’Andrea, L.; A, ; Cet, De; Gastaldi, D.;Baino, F.; Verne', E.; Orlygsson, G.; Vena, P.. - STAMPA. - (2023), pp. 1-1. (Intervento presentato al  convegno CMBBE2023 Symposium – 18th International Symposium on Computer Methods in Biomechanics and Biomedical Engineeringtenutosi a Paris nel 3-5 May 2023).OriginalIn silico characterization of micro-CT based bioactive glass-ceramic scaffoldsPublisher:PublishedDOI:Terms of use:Publisher copyright(Article begins on next page)This article is made available under terms and conditions as specified in the  corresponding bibliographic description inthe repositoryAvailability:This version is available at: 11583/2984120 since: 2023-11-27T11:34:35ZCongress press IN SILICO CHARACTERIZATION OF MICRO-CT BASED BIOACTIVE GLASS-CERAMIC SCAFFOLDS Luca D’Andrea (1), Anna De Cet (1), Dario Gastaldi (1), Francesco Baino (2), Enrica Verné (2), Gissur Orlygsson (3), Pasquale Vena (1)  1. Politecnico di Milano, Department of Chemistry, Materials and Chemical Engineering, Italy; 2. Politecnico di Torino, Italy; 3. Innovation Center Iceland (ICI), Iceland  1. Introduction As the application of bone tissue engineering scaffolds becomes widespread, experimental studies on the effects of different materials and production methods are becoming increasingly complex. Computational models [1] can substantially reduce both the costs and the duration of the development process of these devices. The morphological and mechanical properties of glass-ceramic scaffolds manufactured through foam replication have been investigated through μCT-based computational models.  2. Materials and Methods The scaffolds characterized were obtained using an experimental composition of SiO2-based glass-ceramic called 47.5B-32 [2]. Six different temperatures, ranging from 600°C to 850°C, were used during the sintering process.  The 3D reconstruction of the scaffolds was carried out through μCT images (pixel size 5 μm); two scaffolds for each sintering temperature were considered. The porosity, strut thickness and pore size were determined to characterize the morphology of each cylindrical scaffold, one of which is shown in figure 1. The mechanical characterization was carried out through finite element based simulations with the ParOSol solver. Through an iterative algorithm allowing for damage-based material evolution [1], longitudinal compression was applied to obtain elastic and strength properties.  To appropriately represent the tension-compression strength mismatch of the material, the Drucker-Prager criterion was used.  3. Results The scaffold porosity varies between 50% and 80%. The average pore dimension for sintering temperatures lower than 700°C is 200-800 µm, while higher temperatures present both large pores (200-800 µm) and smaller pores (<100 µm). Strut thickness decreases with sintering temperature from 400 µm to 60 µm. The elastic and strength values of the scaffolds, normalized in respect to the composing material values, also vary between different sintering temperature, ranging from 0.5 to 0.15 and from 0.05 and 0.2 respectively.  4. Discussion and Conclusions Two sets of scaffolds have been defined, based on sintering temperatures due to morphological and mechanical differences: scaffolds sintered below 690°C, the material’s crystallization temperature [2], evidence large pores and thick struts; scaffold sintered at higher temperatures present both large and small pores, reducing the average strut thickness and pore size.  The algorithm used allows for the visualization of the fracture patterns inside the structure.  Comparisons with experimental data [2,3] obtained from the same scaffolds that were computationally reconstructed were carried out to confirm the validity of the methodology.   Figure 1: 3D computational reconstruction of a scaffold sintered at 600°C.  5. References 1. E. Farina et al., Acta Mech. Sinica 37(2) 292-306 (2012). 2. E. Fiume et al., Acta Biomater. 119 405-418 (2021). 3. E. Fiume et al., Appl. Sci. 10(22) 8279 (2020). 

In silico characterization of micro-CT based bioactive glass-ceramic scaffolds

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In silico characterization of micro-CT based bioactive glass-ceramic scaffolds

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