Sparfloxacin and the fluoroquinolones : a review of classification, antibacterial activity, mechanism of action, pharmacokinetic properties, tolerability and pharmaceutical perspectives

Abstract

Foi realizada uma revisão na literatura sobre as quinolonas, classe antibacteriana que possui amplo espectro de ação, enfocando, principalmente, o esparfloxacino, fluorquinolona de terceira geração que possui potente atividade contra bactérias Gram-positivas, como Streptococcus pneumoniae e Staphylococcus auieus inclusive cepas metilina resistentes (MRSA), bactérias Gram-negativas, anaeróbios, Legionella spp, Mycoplasma spp, Chlamydia spp e Mycobacteríum spp.A revision was accomplished in the literature on the quinolones, antibactenal class that presents wide action spectrum, focusing, mainly, the sparfloxacin, third generation fluorquinolone which has potente activity against Gram positive organisms, including Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA), Gram negative organisms, Legionella spp, Mycoplasma spp, Chlamydia spp and Mycobacterium spp, including multidrug resistant organisms