Guterres, Silvia Stanisçuaski

Pohlmann, Adriana Raffin

Santos, J.S.

English

Lume 5.8

caderno d•farmácla ISSN 0102-6593 Órgão Oficial da Faculdade de Farmácia da Universidade Federal do Rio Grande do Sul volume 26, Suplemento, 201 O I TECNOLOGIA FARMACÊUTICA E BIOFARMÁCIA -=f . -~;~·~~ Pharmaceutical technology and biopharmacy 212-------------------------------------------------------=----~----~ SPRAYDRYING OF NANOCAPSULES CONTAINING SUNSCREEN: PRELIMINARY STUDY Santos J.S.1·; Pohlmann A.R.2; Guterres S.S. 1 1• Laboratório de Cosmetologia, Faculdade de Farmácia, UFRGS; 2* Laboratório de Nanopartículas, Instituto de Química, UFRGS. *Aluno Especial início 2010/1 lntroduction: The use of sunscreen is essential to avoid skin damage due to ultraviolet radiations. The nanotechnology has become important in the cosmetic field, especially concerning the sunscreens. The reduction of the substance penetration into the skin layers is the great benefit of the nanoencapsulation, what leads to increase on the effectiveness of the applied sunscreens. 1·2 Besides that, the control of the sunscreen release is also possible, reducing the time for a new application.3 Objective: This work aimed to preliminary optimize a nanocapsule aqueous suspension (NCS) containing octyl methoxycinamate and dry the obtained formulation by spray drying. Materiais and Methods: The nanocapsule suspensions (NCSs) were prepared according to interfacial deposition of preformed polymer method. Three formulations were prepared, by the addition of increasing concentrations of octyl methoxycinnamate (0.8 mL for NCS1, 0.4 mL for NCS2 and 1.2 mL for NCS3), and evaluated by means of the determination of the particle size (laser diffraction). Then, the nanocapsule suspensions containing the highest oil content (NCS3) were prepared in triplicate of batches and the formulations were called NCS3A, NCS38 , NCS3c. These were characterized in terms of pH (potentiometer), particle size (light scattering and laser diffraction) and zeta potential (eletrophoretic mobility). After, the formulation SNC3c was submitted to spray drying (inlet temperatura of 150°C, sample flow of 0.3 L I h). The powder obtained was evaluated by particle size (dry laser diffraction). The yield was calculated dividing the weighted mass, after drying, by the raw materiais sum of masses before spray drying. Results and Discussion: Ali formulations prepared were appropriated regarding particle size. lnitially, the NCS1, NCS2 e NCS3 presented average sizes between 214 nm and 385 nm, without micrometer particles. Because of the high sunscreen content in NCS3 , it was prepared in triplicate. Both size determination methods allowed to check nano-sized particles (between 300 e 361 nm by laser diffraction and between 236 and 282 by light scattering) with low polydispersion (PDI below 0.200). The pH values were 5,20 ± 0,090 for NCS3A, 5,29 ± 0,046 for NCS38 and 5,18 ±0,076 for NCS3c. These pH values were appropriated for skin application. The nanoparticles presented a zeta potential of -3.04 ± 1.35 mV. The dry powder showed a good yield (48,35%) and average particle size of 35,572 1-1m (Table 1 ). Conclusion: Considering the obtained results, the formulations will be dried in the spray drying in triplicate and analyzed in terms of their yield, moisture, assay and morphology. Thus, this study demonstrates the possibility of preparing spray drying nanocapsules containing sunscreen. The powder obtained can be used as a pharmaceutical ingredient, which may be !ater incorporated into semi-solid pharmaceutical forms and may be appropriate for people with skin prone acne. Table 1: Particle Size distribution of the powder by dry laser diffraction: Formulation d(O, 1) d(0,5) Nanocapsules 3.7951-Jm 13. 967 1-1m powder References 1. P. Perugini et ai., lnt.J. Pharm. 246, 37 (2002). 2. A.F. Ourique et ai., lnt. J. Pharm., 352, 1 (2008). 3. M.M Jimenez et ai., lnt. J. Pharm. 272,45 (2004). Acknowledgments: Rede Nanocosméticos CNPq/MCT. d(0,9) 75.3861-Jm d(4,3) Span 35,572 5.126 

Spray drying of nanocapsules containing sunscreen : preliminary study

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Spray drying of nanocapsules containing sunscreen : preliminary study

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