Funding Information: The TENTACLE-Rectum study was funded by Medtronic External Research Program. The authors declare no other conflict of interest.Peer reviewedPublisher PD

Amano, Takahiro

Atienza, Paula González

Bislenghi, Gabriele

Bremers, Andreas J.A.

Cholewa, Hannia

Collard, Maxime K.

D'Hoore, André

de Lacy, F. Borja

de Vriendt, Stefanie

de Wilt, Johannes H.W.

Denost, Quentin

Farguell, Jordi

Ferenschild, Floris T.

Frasson, Matteo

Frontali, Alice

Fujiwara, Hajime

Gonzalez, Ricardo

Greijdanus, Nynke G.

Gruter, Alexander A.J.

Hannink, Gerjon

Hazen, Sanne J.A.

Hompes, Roel

Konishi, Tsuyoshi

Kusters, Miranda

Lacy, Antonio M.

Lefevre, Jérémie H.

Mattioni, Laura A.

Muriel, Jorge Sancho

Obihara, Ndidi J.

Panis, Yves

Parc, Yann

Pennings, Alexander

Perez, Rodrigo O.

Polat, Fatih

Polle, Sebastiaan W.

Rosman, Camiel

Rotholtz, Nicolas

Ruiz, Hernan

Rutegård, Martin

Salomon, Mario

Solomon, Michael

Talboom, Kevin

Tanis, Pieter J.

Tuynmann, Jurriaan B.

Ubels, Sander

Vailati, Bruna B.

van Kessel, Charlotte S.

van Workum, Frans

Voron, Thibault

Wienholts, Kiedo

Wolthuis, Albert

British Journal of Surgery

English

Funding Information: The TENTACLE-Rectum study was funded by Medtronic External Research Program. The authors declare no other conflict of interest.Peer reviewe

Ramsay, George

TENTACLE-Rectum Collaborative Group

Aberdeen University Research

Stoma-free survival after anastomotic leak following rectal cancer resection : worldwide cohort of 2470 patients

Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied. Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2: 1). Results: Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days). Conclusion: Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding

Maastricht University Research Portal

Stoma-free survival after anastomotic leak following rectal cancer resection:worldwide cohort of 2470 patients

https://aura.abdn.ac.uk/bitstream/2164/22684/1/Greijdanus_etal_BJS_Stoma_Free_Survival_VoR.pdf

Stoma-free survival after anastomotic leak following rectal cancer resection : worldwide cohort of 2470 patients

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Maastricht University Research Portal