Enterprise Systems (ESs) integrate business processes to enhance organizational effectiveness. Organizations make huge investments in procuring and implementing ESs to effectively manage their resources to achieve strategic decision-making and improve operational excellence. Irrespective of the investments, it has become increasingly difficult to reap the full benefits of the systems being implemented. ESs implementation is a massive change event in organizations and in employees’ work routines that affect their day-to-day business activities impacting their job outcomes. To this end, the primary aim of this systematic literature review (SLR) is to synthesize the prior literature that explored the association between ESs implementation and employee job outcomes. Accordingly, our review study systematically analysed fifty empirical studies to identify themes that received substantial attention in the prior literature. The SLR uncovered key gaps, unearthed six themes, identified potential research areas, and proposed a comprehensive framework depicting the current research profile and potential avenues linking ESs and employee job outcomes. Our review provides significant implications for practice and research through the proposed comprehensive framework. We further suggest that ESs implementors need to consider job outcomes as crucial parameters during and post-implementation as successful implementation provides a strategic advantage to organizations and benefits employees