The development of current and next-generation high-performance electronic devices has led to miniaturization in more densely packed spaces. The increasing power levels have resulted in ever-increasing heat flux densities which necessitates the evolution of new liquid-based heat exchange technologies. Implementation of single-phase cooling systems using pulsating flow is viewed as a potential solution to the problems involving high energy density electronics. This work involves a combined experimental and numerical analysis of pulsating flows in a rectangular mini channel undergoing asymmetric sinusoidal flow pulsation formats. The mini channel design includes a heated bottom section approximated as a constant heat flux boundary by uniformly heating a 12.5 μm thick Inconel foil. Infrared thermography (IRT) is used for thermal measurements of the heated boundary from the hydrodynamically and thermally developed region of the mini channel. A 3-D conjugate heat transfer ANSYS CFX model is used for simulations. Asymmetric sinusoidal pulsating flows in the form of leading and lagging profiles with Womersley number of 2.5 and a flow rate amplitude ratio of 0.5 and 3 are investigated