The nasal frontier : decoding the acute stage of PRRSV and ASFV infec,on, resul,ng in new insights in porcine nasal macrophages

Abstract

Porcine reproductive and respiratory syndrome (PRRSV) and African swine fever (ASFV) are two of the most economically important infectious viruses in pigs. PRRSV, a positive-strand RNA virus, causes reproductive failure in breeding pigs and respiratory illness across all age groups. ASFV, a double-stranded DNA virus, is the cause of a severe disease, characterized by high fever and hemorrhages with a mortality rate as high as 100%. Transmission of these viruses occurs mainly through direct contact with infected animals or inhaling viral particles containing droplets. Pigs are particularly susceptible to these transmission routes due to their innate behaviors such as exploring and socializing using their noses. The transmission is increased in pig farming settings where pigs are housed at high densities and in closed units

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