Advances in lung cancer organoid research

Abstract

Lung cancer has high morbidity and mortality rate. Thus, an efficient pre-clinical model that can serve the translational study is urgently needed. The application of organoid should be compared to existing in vitro and in vivo models under different circumstances. The development of organoids of lung cancer has undergone three stages as tissue-specific stem cell differentiation, mixed cell manipulation, and 2-dimensional cultivation. Now, lung cancer organoid can be developed from samples harvested through surgery, biopsy, and circulating tumor cells, with a wide range of application. This review aims to summarize the historical development and application of lung cancer organoids