This study aimed to detect the salinity harsh influence on germination of Triticum aestivum L. seeds, seedling growth and some physiological defense mechanisms to determine the salt- tolerant genotype. The study conducted as a completely randomized design with 3 replicates for each treatment. Four bread wheat genotypes; Hawler- 2, Azady, Adana, Rabeae were subjected to two irrigation patterns; tape water (control) and 100 mM NaCl (salt stress). The highest percent of germination; 46.77 recorded by Rabeaa genotype. Meanwhile Azady and Rabeaa had highest mean germination time (MGT); 16.71 and 16.03 respectively. Longest root was exhibited by Adena;10.50 cm. while longest shoot represented by Hawler-2; 16.40 cm. Highest dry weight of root was 1.01 g. Root: shoot ratio; 1.63 exhibited by Rabeaa. Hawler- 2 showed minimum chlorophyll a; 0.90 mg/ g. Lowest chlorophyll b and total content observed in Adena; 2.18 and 2.3 mg g-1 respectively. Azady and Rabeaa recorded higher MSI%; 43.3 and 43 % respectively as compared to others. Rabeaa recorded highest water content, proline and sugar content; 22.7, 0.31 and 11.56 mg g-1. Therefore, it could suggest that Rabea and Azady can be successfully grown under 100 mM NaCl saline condition