Prostate cancer (PCa), the most prevalent epithelial malignant neoplasm in the
male group globally, is the fifth largest cause of cancer-related death in males.
ZW10 Interactor (ZWINT) is involved in the chromosome
segregation process, which is linked to the formation of several tumor cells.
However, its function in PCa remains unknown. Therefore, our aim was to explore
the potential mechanisms of ZWINT in PCa progression. We obtained
RNA-seq as well as clinical data from The Cancer Genome Atlas Program (TCGA),
University of California Santa Cruz (UCSC) database. Assessment of ZWINT
expression in clinical subgroups, immune infiltration, and prognostic relevance
using the R program. Search Tool for Recurring Instances of Neighbouring Genes
(STRING) tool was applied to construct a ZWINT co-expression network and
the potential biological functions involved in differentially expressed genes
(DEGs) were investigated by enrichment analysis. ZWINT was
upregulated in prostate cancer tissues and showed to be significantly associated
with T stage, N stages, Gleason score (GS), and prognosis of prostate cancer
patients. Functional enrichment analysis revealed that ZWINT-related
genes were mainly related to cell cycle, meiosis, myogenic fiber synthesis, and
muscle contraction. In addition, High-expression of ZWINT may have
possessed immunosuppressive effects through adverse regulation of several immune
cells and factors. ZWINT is overexpressed in prostate cancer and
correlated with immune infiltration, which is expected to be a potential
biomarker for PCa prognosis
