The CERN accelerator complex stopped operation at the end of 2018 for the Long Shutdown 2 (LS2), allowing for the LHC Injector Upgrade program (LIU) and consolidation work to be accomplished. A gradual restart of the different accelerators is ongoing in 2021, culminating with the LHC foreseen to be back in operation early 2022. During LS2 a very large range of systems was modified throughout the accelerator complex. This includes the so-called Machine Interlock systems, which are at the heart of the overall machine protection system. This paper gives an overview of the Machine Interlock systems changes during LS2. It includes the installation of a Beam Interlock System (BIS) at the new linear accelerator LINAC4, at the PS-Booster and the installation of a new Injection BIS for the SPS synchrotron. New Safe Machine Parameter flags to protect the SPS transfer line mobile beam dumps against high intensity beams were put in place. The new Warm Magnet Controller (WIC) installations at LINAC4 the PS Booster and the different transfer lines and experimental areas are presented together with the modifications to the Power Interlock Controller protecting the LHC superconducting magnets