This thesis had four main objectives:Predictors of Bipolar disorder (BD): Chapters 2 and 3 explored factors contributing to Bipolar Disorder's development and progression, considering both internal and external influences.External Stressors: Chapter 4 investigated how external stressors, particularly the COVID-19 pandemic, impacted the stability of BD symptoms, highlighting the role of environmental factors.Symptom Interactions: Chapter 5 analyzed the complex interplay of mania and depressive symptoms in BD over time, enhancing our understanding of their evolution.Neurocognition and Brain Functioning: Chapter 6 reviewed long-term cognitive (dys)function and brain activity in BD patients, offering insights into the disorder's neural mechanisms.Overall, the thesis aimed to expand knowledge of BD, encompassing its predictors, the influence of external stressors, symptom dynamics, and neurocognitive aspects. This research contributes to better diagnosis and treatment strategies for individuals affected by BD.LUMC / Geneeskund
